Why urine instead of blood?
Urine as a carrier of information is very stable.
When the urine leaves the bladder, degradation processes (so-called proteolytic processes) are already completed. Almost no additional degradation takes place after the urine sample has been collected. Storage at -18 ºC allows the information to be retained for years.
Information in the blood decays easily.
The carrier of information in the blood are degraded by proteases shortly after collection; the blood coagulates. The amount of information contained in the blood thus depends strongly on the coagulation time: the collected blood must be processed as quickly as possible. Immediate centrifugation and cooling are necessary to limit the destruction of the information content in the blood. Only storage at -80 ºC allows the remaining information to be preserved for a longer period of time.
First separation, then decoding.
The proteins can be separated by the use of the DiaPat® technology. Urine is very well suited for this purpose because it contains a large number of informative proteins - without irrelevant components such as fats or blood cells that make it difficult to decode relevant information. The information carriers are already present in urine in a purified form.
In addition to the relevant proteins, blood also contains a large number of irrelevant components and it is difficult to separate them from the carrier of information.
The more meaningful the information, the more accurate the diagnosis
In urine, we extract the information from several thousand proteins, which enables particularly meaningful and early detection of diseases.
Blood is usually used to determine a few specific proteins.
Uncomplicated handling facilitates the process
A urine sample is easy to obtain, the information is stable and the sample is easy to handle.
Blood collection requires healthcare professionals, timely processing, and cooling.