Frequently Asked Questions
- Reliable - precise detection of disease
- Efficient - only a urine sample required
- Early diagnosis - detection of diseases at an early stage
- Long-term - efficacy of applied therapies can be monitored
The DiaPat® test analyses urine. For the test urine is collected into a urine cup*. Subsequently, the urine is transferred into an enclosed urine "monovette" container* and immediately stored at -12°C For shipment, the deep frozen monovette is placed into a protection package*. Shipment is carried out with dry ice in a transport carton* to our central laboratory.
* All items necessary for the procedure are provided.
The DiaPat® test was validated in clinical studies and proved to be a reliable diagnostic tool. Its main advantage is the determination of a biomarker profile instead of a single biomarker.
The DiaPat® diagnostic method complies with the EU directive on in-vitro diagnostic medical devices (IVD) (98/79/EG). The method is therefore approved for use by qualified medical staff.
The DiaPat® technology is based on the fact that diseases are reflected by the protein composition of body fluids. World wide this knowledge is routinely used for diagnostic purposes. The test applies capillary electrophoresis coupled mass spectrometry (CE-MS) The urinary proteins are separated in an electric field by the capillary electrophoresis and are subsequently analysed in a mass spectrometer; a molecular balance that measures the molecular weight of the proteins. The obtained data sets are digitally compared with a disease specific DiaPat® biomarker profile (diagnostic pattern) to identify patients at high risk.
Proteomics is the systematic study of a proteome, i.e. the entire complements of proteins of either part of or an entire organism. Proteins play a central role in our bodies. A deeper insight into the functional relevance of these proteins under healthy or diseased conditions is the main challenge in clinical research. Alterations in concentration or modification of proteins can indicate diseases. Such kind of disease indicating proteins are called biomarkers.
The word "proteome" is a combination of "protein" and "genome" (genome = the entire set of genes of an organism). Whereas the proteome is highly variable and adaptive, the genome is quite invariant and constant. Therefore proteomic changes are highly suitable to depict the state of an organism.